In 1965, Professor Brånemark placed the first dental implant in the human body, and in 1985, he famously stated, “When I see a yellow bone, I cancel the implant surgery!” Why do we mention this here? Because FDOJ, by its tissue composition, is degenerative bone and fatty tissue. Clinically, it appears yellow, mixed with blood and bone fragments, and, as proven in our own studies, contains elevated levels of the inflammatory mediator CCL5. This mediator binds to CCR5 receptors found throughout the body. Constant release of the CCL5 chemokine means continuous activation of the CCR5 receptor, which is associated with chronic diseases and even cancer. For those interested, here are two relevant publications.(Nature, NCBI) izmed mnogih.

Issues with bone healing, particularly in relation to implants, have already been documented. It is well known that the immune system plays a significant role in bone health and disease. It also plays a crucial role in bone regeneration during the healing of bone wounds, including in the oral cavity. Chronic inflammation consistently leads to increased production of oxidants, and an imbalance between oxidants and antioxidants results in oxidative stress for the body. This stress causes damage at the cellular and molecular levels, ultimately leading to cell damage, DNA changes, and cell death, which, in turn, results in impaired wound healing. Following this example, we conducted an analysis of vitamin D levels in our patient population, with the findings displayed in the graph below. Additionally, his latest work was published in a new article this February, and those interested can follow it here.

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The mouth, with its teeth, soft tissues, and bone, is truly unique, and there is no comparable situation elsewhere in the body. At this link, you can find a master’s thesis written in 2022 on this very topic, which thoroughly explains the entire concept of so-called Fatty Degenerative Osteonecrosis, or FDOJ.