Widely unrecognised pathology in the jawbone produces an inflammatory messenger known as chemokine RANTES/CCL5. These local chronic RANTES inflammatory signalling cascades propel undesirable dysregulations in the immune system: Individual organs derail inflammatory or degenerative. Thus, the development of rheumatism, fibromyalgia and depression can be traced back to the RANTES pathways, as can the promotion of tumours or neuroinflammatory and neurodegenerative diseases such as multiple sclerosis or Parkinson’s disease. The systemic effect of RANTES on the body thus acts like a “creeping poison”. The removal of these RANTES foci in a simple dental surgery Jawbone Detox® procedure results in impressive healing. Why is this new in dentistry? RANTES jawbone foci are not to detect by conventional X-ray. Alternatively new transalveolar ultrasonography (TAU/www.cavitau.de ) device is available for a radiation-free diagnosis of bone density and able to objectivize the fatty-degenerative condition of jawbone beyond radiography. This opens a new aspect for future Integrative Oral Medicine and Preventive Integrative Medicine and Dentistry.