Stage 6

Dedifferentiation stage 6 is the last stage in which cells genetic material is damaged and new growth (cancer) has emerged.

If patients still don't act with the correct integrative medicine strategy, the buildup of noxious agents, aka "garbage" damages the cell`s genetic material and severely affects cellular respiratory mechanisms.


Diagnoses that fall into this group are basically all forms of cancer. Especially in this stage, we work together with our good partner clinic from Switzerland, Biomedicine Sonnenberg which has plenty of experience in the integrative oncology field, and together we have great success.


Logically, therapies in this stage must be carefully planned, and besides all of the explanations in the first five stages, in stage 6, strictness in the removal of chronic foci is mandatory. This includes periodontal disease, “dead” teeth, metals in the mouth, and any scars in the body. Working the gut microbiome is of the essence since 80% of the immune system grows in the walls of the intestines. Integrative oncology offers a series of direct antitumor substances and specific blood tests for testing the effectiveness of chemotherapy agents and integrative medicine anticancer agents in order to make treatment as effective as possible. All the other strategies are in essence the same as in previous phases since the body still needs to unload the accumulated toxic burden.

This stage is a final consequence of failed control of the accumulation of exogenous and endogenous noxious agents. Free radicals continue to promote organ dysfunction and tissue degeneration. Cellular metabolism is no longer oxidative phosphorylation, but it changes to “fermentation”, which means “breathing” on a cellular level. The dedifferentiated cells are then released into blood circulation. In general, at this stage, we must be aware that the organism has severely reduced its energy reserves and its regulatory capacity.

Stage 5

The degeneration stage is marked by deeper intracellular noxious agents which is accompanied by reduced cell function.

Cells are by now severely damaged, restoration of the cell's membrane, enzymes, other proteins, and genetic material is crucial.


If there is still no therapeutically planned detoxification with drainage in combination with upbuilding treatment done and only suppressive medication is employed, then organ structure and its function are increasingly and irreversibly damaged.

Typical diagnoses in phase 5 are dermatoses including psoriasis, periodontal disease, Atrophic rhinitis, Parkinson’s’ disease, Alzheimer’s disease, ALS, Macular degeneration, glaucoma, Addison`s disease, COPD, Chron disease, ulcerative colitis, Hashimoto disease, Scleroderma, Osteoporosis, Arthrosis, Ankylosing spondylitis, Myocardial infarction, etc.


Treatment continues with the activation of general bodily defenses to elicit efficacious reactive stage 1 and 2 with neural therapy, homeopathy, herbals, ozone therapy, acupuncture, etc. In targeted antioxidant therapy, as we wrote elsewhere, reactive oxygen species are further produced in this phase. Activation of drainage of organs and extracellular matrix in the microscopic world means draining of cells with specific orthomolecular detoxification, herbal sauna, other medical ayurvedic techniques, colon hydrotherapy or enemas, etc. It is necessary to increase membrane potential since it is lowered with the deepening of the disease process with alkaline minerals like magnesium, potassium, calcium, and also essential fatty acids. Among many therapeutic approaches, Papimi is extremely effective in this case. Again, special attention must be taken to the use of suppressing pharmaceuticals and smartly and carefully adjusting the dosing during the treatments. During treatment, an orthomolecular strategy must be prescribed and planned. As always, the most important part and the part that you, as a patient, have complete control over is taking care of adequate hydration and reducing the dietary antigenic and toxic load.

Continuous degenerative harm is done to the cells with an effect on genetic and other structures like membranes, enzymes, other proteins, etc. Inevitable toxin accumulation continues, which just multiplies with chronic inflammation. It is valid to say that toxins at this stage due to glandular impregnation cause hormonal imbalance and reduced capacity for immunomodulation. In the end, the body’s defenses in terms of inflammation and cells themselves are so suppressed that the proliferation of anomalous cells occurs. At this stage, improvements are possible, but it is fair to say that full recovery MAY not be possible even with an integrative approach. However, with the modern integration of all medical knowledge and long-term treatment, everything is possible. The focus is always on supporting cell function and improving affected regulation. Again, we must not forget proper oral health, as described elsewhere. Cellular support is planned based on diagnostics, with the main aim being increasing ATP energy production through vitamins, herbs, homeopathic and supporting therapies such as Papimi ion therapy local radiofrequency hyperthermia therapy, and many others. In this way, cells get the basics in order to regain their specialized function and ability to excrete metabolism byproducts and toxic load.

Stage 4

Stage 4: causative noxious agents have penetrated into the cells. The treatment strategy must include cellular detoxification.

In this phase, the noxius agents damage the cell membranes, enzymes, etc.


Diagnoses that fall into this stage are migraine, eye twitching, viral infections, asthma, ulcers, toxic liver damage, nephrotic syndrome, autoimmune glomerulonephritis, chronic arthritis, benign prostate hyperplasia, bronchitis, angina pectoris, myocarditis, and many others.

The treatment strategy in this phase is more complex, and at the beginning, it is necessary to support the cellular processes. It is imperative to start with boosting the cellular energy mechanisms with orthomolecular therapy, ion induction therapy, hyperthermia, boosting the catalysts of the citric acid cycle, coenzyme Q10, alpha lipoic acid, vitamin C, specific herbs, and many, many others. In this way, we give the cells the energy they need to excrete disturbing agents into the extracellular matrix and maintain organ function. Since the extracellular matrix is now the “dumping ground”, we need to concurrently activate the drainage of the extracellular matrix itself and all the excretory organs, namely the liver, kidneys, skin, intestinal mucosa through again orthomolecular remedies, herbs, special herbal tonics and oils, and specific therapies. We must not forget to neutralize reactive oxygen species. In a way, it is about triggering an effective stage 2 that is able to remove the disturbing noxious agents from the body. In the clinic, we support this with neural therapy, ozone, cupping, many of the Ayurvedic techniques, and others. Increasing the membrane potential is achieved through ion-induction therapy with Papimi and Indiba accompanied by minerals, essential fatty acids, etc. Pharmaceuticals are used with the awareness that suppression is not desirable at this stage. On the other hand, we have to be extremely strict about oral health at this stage because many of the root causes could originate in the mouth, such as infectious inflammation of the bone and soft tissues (periodontitis, “granuloma”—dead teeth), non-infectious FDOJ, or in older days, NICO, materials (metals and plastics), and also the effects of the bite on postural problems. In the end, of course, more rigor in diet, hydration, etc.

So we observe direct effects on cellular functions, e.g., enzymes, but also on cell membranes and mitochondria. As Reckeweg wrote, at this stage, we are usually presented with a patient who has some form of chronic inflammation. Basically, the inflammation is going on in an extracellular matrix, which, because of its chronicity, leaves damaging after-effects. The whole biochemical imbalance accumulates around organ parenchyma, and the inflammation is just a stage 2 reaction that tries to isolate the noxious situation by “scarring” it. Ultimately, this process damages the organ itself. If the ongoing defense is not treated and detoxification is not initiated, degeneration of the organ structures is inevitable.

Stage 3

Stage 3: The body’s own defense processes cannot manage to completely expel toxins. They are deposited in the extracellular matrix, in adipose tissue, and in the entire vascular system.

At this stage, it is of utmost importance to stimulate cellular metabolism to get rid of deposited material of any origin.


Diagnoses at this stage are atheromas, warts, cysts, polyps, neuromas, constipation, cholelithiasis, obesity, gout, edema, lymph gland swelling, prostatic hypertrophy, fibroids, and rheumatism, to name a few.


  • Specific drainage remedies
  • Specific Ayurvedic treatments
  • Osteopathic drainage treatments
  • Specific papimi Ion-Induction-Therapy regimen
  • Specific local and systemic hyperthermia
  • IHHT: Intermittent hyper, hypoxic treatment
  • Integrative Dentistry

In general, the first 3 stages can be treated with great success if the therapies are planned appropriately and integratively. It must be remembered that these three stages affect the fluid and the extracellular matrix, and the biochemical mechanisms of the cell are not yet damaged. We must be aware that from the 3rd stage until the next 4th stage, the organism does not have an efficient biological defense and draws energy away from detoxification. The cellular metabolic functions need stimulation from your integrative therapist to recover and support the release and gradual elimination of toxin deposits to maintain energy for the vital organs.

The therapeutic strategies in this phase are similar to those in the previous stage. That is, activating the body’s own drainage through the kidneys, liver, skin, and intestinal mucosa and draining the extracellular matrix through the lymphatic and vascular systems We can achieve this by combining Ayurvedic herbal medicine, orthomolecular therapies with either supplements or infusions or both, medicinal saunas, enemas or intestinal hydrotherapy, cupping, homeopathy, and others. When stage 2 defenses are prolonged over time, we need to be wary of oxidative processes. Based on laboratory results and our experience, high doses of antioxidants are prescribed. Again, dietary review is essential to ensure adequate hydration and reduce the antigenic load of food. The activation of immune cell-producing organs such as bone marrow and thymus is essential. The secondary lymphoid organs must not be forgotten. These organs include the lymph nodes, spleen, tonsils, and certain tissues in various mucosal layers of the body (e.g., Peyer`s patches in the intestine).

Stage 2

Stage 2: Reaction Stage
It is characterized by expelling the noxious agents, which can be of internal or external origin.

In this stage, the body`s natural defenses are activated. The most frequent are vomiting, diarrhea, fever and inflammation


This group includes dermatitis, erythema, eczema, stomatitis, rhinitis, herpes zoster, poliomyelitis, neuralgia, pharyngitis, laryngitis, colitis, hepatitis, abscess, osteomyelitis, tonsillitis, and polyarthritis, to name a few.


  • Chemical substances (glyphosate, PFOA, pesticides, DDT, herbicides)
  • Bacteria (streptococci, staphylococci, borrelia, etc.)—most importantly
  • Viruses (EBV, VZV, CMV, Influeza, COVID-19, etc.)—the most relevant
  • Heavy metals (arsenic, cadmium, lead, mercury, etc.)

The most common defenses are fever, diarrhea, and inflammation, and with them can come troublesome symptoms. In integrative medicine, symptoms are seen as a serious attempt by the body to get back to stage 1 health. Symptoms, though annoying, become valuable signs that the organism is attempting to regulate toward recovery. Only in rare cases does one need medication for fever, pain, and inflammation. More so, overuse of so-called NSAID drugs can progress the disease to deeper stages. In some cases, they are used, and the dosage has to be chosen carefully.

The therapeutic strategies at this stage are to activate the drainage of organs such as the kidneys, liver, skin, and intestinal mucosa, as well as the drainage of the extracellular matrix, as described elsewhere. We can achieve this by combining Ayurvedic herbal medicine, orthomolecular therapies with either supplements or infusions or both, medicinal saunas, enemas or colon hydrotherapy, homeopathy, and others. When inflammation is prolonged, we need to be wary of reactive oxidative species in layman’s terms. We need to watch out for high levels of antioxidants, based on laboratory results and our experience. Again, dietary review is imperative to ensure adequate hydration and reduce the antigenic load of food.

Stage 1


In this stage, natural bodily detoxification pathways should work normally.


Excretion is a prerequisite for the human body to function normally in daily life. This stage is always addressed with therapies, regardless of the diagnosis. We must ensure that numerous endogenous detoxification mechanisms function normally and intervene at the first signs of internal or external noxious agents that block excretion. The excretory pathways are sweat, sebum, saliva, gastrointestinal secretions, bile, pancreatic juice, menstruation, lymph, urine, menstruation, semen, etc.

Excretion of harmful substances normally occurs through the physiological orifices of the body. For example, vomiting or diarrhea normally only require the replacement of fluids and electrolytes

We normally test the major excretory pathways in the blood, for example, glutathione transferase, superoxide dismutase, cystatin C, and others. Surprisingly, all these detoxification enzymes need to be activated.


Since fluids make up the majority of our bodies, it is important that we stay hydrated. Water is the medium in which all biochemical reactions take place, and if there is not enough water, the body`s biochemistry cannot function. It is the same as if you wanted to dissolve a spoonful of salt in a glass of water.

We always advise organic food and locally sourced if possible. Avoid all processed foods, even if they are organic. We often test for elevated levels of glyphosate in the blood. One patient was even positive for DDT. We always advise avoiding cow’s milk products because of the increased levels of beta-lactoglobulin, and all our patients are extremely happy when they do this. We normally advise eating as little gluten as possible and, of course, strictly avoiding sugar.

Biological dentistry: fundamentals and effective Methods: Preventive measures and therapeutic approaches to promote bone and soft tissue healing.

Biological dentistry: fundamentals and effective Methods: Preventive measures and therapeutic approaches to promote bone and soft tissue healing.

Biological Dentistry is a dynamic field that recognizes the intricate interplay between oral health and systemic well-being. This abstract provides a comprehensive exploration of the core principles and practical applications within Biological Dentistry, highlighting its significance in the context of modern healthcare’s shift towards prioritizing healthspan over mere lifespan.

At the heart of Biological Dentistry lies the profound recognition that oral health is not an isolated concern but an integral component of overall well-being. This understanding begins with a detailed examination of the microbiome and osteoimmunology, two pillars that underpin the biological mechanisms governing oral health.

The oral cavity houses a thriving ecosystem, hosting a diverse community of microorganisms, including over 700 distinct bacterial species, viruses, and fungi. These inhabitants, along with their metabolites and pro-inflammatory mediators, wield a remarkable capacity to exert influence far beyond their immediate domain. Specific attention is devoted to pathogenic microorganisms such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. These bacteria, recognized for their roles not only in causing localized oral conditions but also in driving systemic implications, illustrate the interconnectedness of oral and systemic health. Porphyromonas gingivalis, for instance, has been closely associated with gut dysbiosis and its potential to disrupt the gut microbiome equilibrium. Additionally, the secretion of gingipain by this bacterium has been implicated in the progression of Alzheimer’s disease. Likewise, Aggregatibacter actinomycetemcomitans is examined for its potential to heighten the metastatic potential of pancreatic cancer, thereby highlighting the systemic consequences of oral health. Crucially, the influence of these bacteria often manifests through inflammatory responses, reinforcing the central role of inflammation in both local and systemic pathologies.

Osteoimmunology, a burgeoning field investigating the intricate interaction between the immune system and bone metabolism, assumes critical importance in comprehending the complex relationship between inflammation and bone health. A paradigm shift from viewing bones as static structures to dynamic, continuously remodeling tissues is articulated. The regulatory mechanisms governing this remodeling process, notably RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which modulate the activity of osteoclasts, are elucidated. Particular emphasis is placed on the influence of bacterial lipopolysaccharides, with Porphyromonas gingivalis as a notable example. These lipopolysaccharides have been shown to upregulate RANKL expression in osteoblasts, ultimately leading to bone loss in periodontal disease.

This exploration underscores the critical need to recognize the intricate connections between oral health, the microbiome, osteoimmunology, and systemic well-being. Such recognition not only underscores the need for a comprehensive approach but also aligns with the evolving paradigm of modern healthcare, which increasingly focuses on healthspan over lifespan. Today’s healthcare system recognizes that longevity alone does not equate to quality of life. Instead, the emphasis is shifting towards enhancing healthspan – the period of life marked by good health and well-being. In this context, Biological Dentistry takes on a pivotal role, as it acknowledges that oral health is an integral element of overall healthspan.

In conclusion, this comprehensive exploration underscores the vital importance of Biological Dentistry within the evolving landscape of modern healthcare. It serves as a compelling argument for healthcare systems to prioritize healthspan, promoting both oral and overall health through a deeper understanding of the connections between oral health, the microbiome, osteoimmunology, and systemic well-being. This paradigm shift represents a crucial step towards enhancing the quality of life for individuals across the lifespan.

Unveiling the Oral Systemic Axis: Exploring the Role of Microbiome and Osteoimmunology in Biological Dentistry

Unveiling the Oral-Systemic Axis: Exploring the Role of Microbiome and Osteoimmunology in Biological Dentistry

Biological Dentistry emerges as a burgeoning field acknowledging the intricate interplay between oral well being and systemic health.

This abstract delves into the indispensable role of the microbiome and osteoimmunology as pivotal elements influencing ove rall systemic health within the domain of dentistry. Within the oral cavity resides a myriad of diverse bacteria, viruses, and fungi, comprising a staggering 700 distinct species. These microorganisms, together with their byproducts and inflammatory mediat ors, have the potential to traverse various pathways, including ingestion via saliva, thereby potentially exerting an impact on other bodily regions.

Research studies have illuminated the significance of specific bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, not only in causing localized oral ailments but also in bearing systemic ramifications. Porphyromonas gingivalis has been associated with gut dysbiosis, as it manages to withstand the harshness of stomach acid an d disrupts the equilibrium of the gut microbiome. Additionally, the gingipain secreted by this bacterium has been implicated in the progression of Alzheimer’s disease. Conversely, Aggregatibacter actinomycetemcomitans has been discovered to heighten the me tastatic potential of pancreatic cancer. Rather than directly causing destruction, the inflammatory response triggered by these bacteria contributes to the deterioration of tooth supporting tissues and aggravates systemic inflammation.

Osteoimmunology, th e field that studies the interaction between the immune system and bone metabolism, offers valuable insights into the intricate relationship between inflammation and bone health. Previously viewed as relatively inert, bone is now recognized as a dynamic ti ssue undergoing constant remodeling. This process is governed by diverse factors, including RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which regulate osteoclast activity. Bacterial lipopolysaccharides, such as th ose emanating from Porphyromonas gingivalis, have been demonstrated to enhance RANKL expression in osteoblasts, leading to bone loss in periodontal disease.

Appreciating these complex connections between oral health, the microbiome, osteoimmunology, and s ystemic health is of paramount significance within the realm of biological dentistry. By acknowledging the influence of oral pathogens and inflammation on systemic well being, a comprehensive approach can be embraced to foster both oral and overall health.

In the pursuit of enhancing osseointegration and implant stability, a pilot study was conducted utilizing a unique Ion Induction Therapy (IIT) protocol, along with IV Ozone. Preliminary results showcased remarkable outcomes, with Osstell ISQ scores avera ging 72 after 16 weeks post op. This data presents a notable advantage over a comparable study by Vladimir Kokovic et al., which achieved an average ISQ value of 64 for the same type of implant. Notably, ISQ scores above 70 indicate high stability, 60 69 s ignify medium stability, and scores below 60 denote low stability. This promising integration of IIT and IV Ozone highlights the potential to elevate osseointegration, thereby underlining the practical impact of these interventions in the realm of biologic al dentistry.

Further exploration through research endeavors and clinical investigations is warranted to advance our comprehension and devise effective strategies in biological dentistry, ultimately enhancing patient outcomes and systemic well being.

Dr. med. dent. Sebastjan Perko, Phd.

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Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health.

Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health.

Biological Dentistry is an emerging field that recognizes the interplay between oral health and systemic health. This abstract explores the pivotal role of the microbiome and osteoimmunology as key factors influencing overall systemic health in the context of dentistry.

The oral cavity harbors a diverse array of bacteria, viruses, and fungi, with over 700 different species residing in the mouth. These microorganisms, along with their byproducts and inflammatory mediators, can travel through pathways such as saliva ingestion, potentially impacting other parts of the body.

Studies have revealed that certain bacteria, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, not only cause localized oral diseases but can also have systemic implications. Porphyromonas gingivalis has been linked to gut dysbiosis, surviving stomach acid and disrupting the gut microbiome. Moreover, gingipain secreted by this bacterium has been implicated in the development of Alzheimer’s disease. Aggregatibacter actinomycetemcomitans, on the other hand, has been found to increase the metastatic potential of pancreatic cancer. The inflammatory response triggered by these bacteria, rather than their direct destruction, contributes to the breakdown of tooth-bearing tissues and feeds into systemic inflammation.

Osteoimmunology, the study of the interaction between the immune system and bone metabolism, provides insights into the complex relationship between inflammation and bone health. Bone, once considered relatively inert, is now recognized as a dynamic tissue undergoing constant remodeling. This process is regulated by various factors, including RANKL (receptor activator of nuclear factor kappa B ligand) and OPG (osteoprotegerin), which modulate osteoclast activity. Bacterial lipopolysaccharides, such as those from Porphyromonas gingivalis, have been shown to increase RANKL expression in osteoblasts, resulting in bone loss in periodontal disease.

Understanding these intricate connections between oral health, the microbiome, osteoimmunology, and systemic health is of utmost importance in biological dentistry. By considering the impact of oral pathogens and inflammation on systemic health, a comprehensive approach can be adopted to promote oral and overall well-being. Further research and clinical investigations are warranted to advance our understanding and develop effective strategies in biological dentistry to improve patient outcomes and systemic health.

Blood Tests to Determine the Impact of the Mouth on the Body

Blood Tests to Determine the Impact of the Mouth on the Body

Integrative medicine does not exist without biological dentistry. The mouth with teeth is part of the body that, with its inflammatory conditions and metallic materials, affects health.

At the same time, any body therapy cannot be effective if the body is burdened with oral conditions. Infections can lead to periodontitis or periodontal disease, “dead” teeth with granulomas, and among the metals, there is amalgam containing mercury, as well as most metallic alloys used in bridges and dentures. Inflammation creates an acidic environment, accelerating the “dissolution” of metals that deposit in the body.

In biological dentistry, thorough diagnostics are crucial, including oral examinations, even with a microscope, computer analysis of the periodontal disease status, X-rays, including CBCT, Dark Field microscopy, analysis of inflammatory mediators, etc.

When the diagnostics reveal what needs to be done, the therapeutic phase follows, in which we strictly follow protein-free and biocompatible trends. All materials are carefully selected and body-friendly. In surgery, we use techniques such as PRF, ozone, and PMP – pulsed magnetic field after procedures. These approaches allow us to avoid the use of antibiotics, significantly reducing complications and pain after procedures. In the field of dentures and bridges, we exclusively practice digital dentistry, which provides excellent precision and comfort. If you experience anxiety, we also offer inhalation sedation, “laughing gas,” to provide relaxation before and during procedures.

Blood Tests to Determine the Impact of the Mouth on the Body

  • For those who have already been diagnosed with any condition and wish to understand its causes and eliminate them.
  • For individuals who have experienced illness and are in the rehabilitation phase in one way or another.
  • For those who perceive symptoms of imbalance but have not yet developed specific disease signs.
  • For healthy individuals who want to strengthen their body and mind and maintain their well-being in the long run.